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The effects of scleroderma serum on human microvascular endothelial cells. Induction of antibody-dependent cellular
R M Marks1, M Czerniecki, B S Andrews
1Centre for Immunology, University of New South Wales, Sydney, Australia.
Arthritis and Rheumatism
|December 1, 1988
Abstract:
To investigate the vascular immunopathology of systemic sclerosis, we developed a model consisting of human microvascular endothelial cells, leukocytes, and serum. Sera from 19% of the patients studied mediated antibody-dependent cellular cytotoxicity against endothelial cells. Some sera also mediated cytotoxicity against aortic endothelium and fibroblasts. K lymphocytes, the cells that mediate antibody-dependent cellular cytotoxicity, were identified in the skin of some patients. The sera alone were not cytotoxic or growth inhibitory, and did not affect endothelial prostacyclin production.