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Left Ventricular Longitudinal Systolic Function in Septic Shock Patients with Normal Ejection Fraction: A

Hong-Min Zhang1, Xiao-Ting Wang1, Li-Na Zhang2

  • 1Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.

Chinese Medical Journal
|May 10, 2017
PubMed
Summary

Septic cardiomyopathy can be detected earlier using longitudinal systolic function (LSF) than left ventricular ejection fraction (LVEF). LSF parameters like mitral annular plane systolic excursion (MAPSE) and tissue Doppler velocity (Sa) are more sensitive indicators of cardiac dysfunction in septic shock patients.

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Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Echocardiography

Background:

  • Septic cardiomyopathy is a frequent complication in septic shock.
  • Left ventricular ejection fraction (LVEF) is the standard measure for septic cardiomyopathy.
  • Early detection of cardiac dysfunction is crucial for patient outcomes.

Purpose of the Study:

  • To compare the sensitivity of left ventricular longitudinal systolic function (LSF) versus LVEF in assessing heart function in septic shock patients.
  • To identify more sensitive echocardiographic parameters for cardiac depression in sepsis.

Main Methods:

  • A case-control study involving 45 septic shock patients and 45 non-sepsis controls.
  • Transthoracic echocardiography was used to measure LVEF, mitral annular plane systolic excursion (MAPSE), and tissue Doppler velocity (Sa).
  • Comparison of LSF parameters and LVEF between septic shock and control groups.

Main Results:

  • No significant difference in LVEF was observed between septic shock and control groups (P=0.161).
  • MAPSE was significantly lower in septic shock patients compared to controls (P<0.001).
  • Sa was also significantly reduced in septic shock patients (P=0.014).

Conclusions:

  • Longitudinal systolic function (LSF) parameters, including MAPSE and Sa, are more sensitive than LVEF in detecting cardiac depression in septic shock.
  • Clinicians should prioritize LSF assessment in septic shock patients, especially those with normal LVEF.
  • LSF parameters offer a more sensitive approach to heart function appraisal in septic shock.