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Multicystic biliary hamartoma with extremely elevated CA19-9: a case report
Takeshi Morinaga1, Katsunori Imai1, Yo-Ichi Yamashita1
1a Department of Gastroenterological Surgery, Graduate School of Life Sciences , Kumamoto University , Kumamoto , Japan.
Scandinavian Journal of Gastroenterology
|May 10, 2017
Summary
Multicystic biliary hamartoma (MCBH), a rare liver condition, can present with significantly elevated serum carbohydrate antigen (CA) 19-9 levels. Surgical removal of MCBH led to a notable decrease in CA 19-9, aiding diagnosis.
Area of Science:
- Hepatology
- Gastroenterology
- Oncology
Background:
- Multicystic biliary hamartoma (MCBH) is an uncommon benign cystic liver lesion.
- Elevated serum carbohydrate antigen (CA) 19-9 levels typically raise concern for malignant biliary or pancreatic neoplasms.
Observation:
- A 53-year-old male presented with extremely elevated CA 19-9 (>12,000 U/mL).
- Imaging revealed a multicystic liver lesion with a calcified wall in the left lobe.
- No intracystic nodules were detected, making malignancy less likely but still considered.
Findings:
- Postoperative pathological examination confirmed the diagnosis of MCBH.
- Serum CA 19-9 levels significantly decreased after surgical resection of the hamartoma.
- This case highlights an unusual presentation of MCBH with markedly elevated CA 19-9.
Implications:
- MCBH should be considered in the differential diagnosis of liver lesions associated with extremely high CA 19-9 levels.
- This case underscores the importance of comprehensive histopathological evaluation for accurate diagnosis.
- Understanding this association may improve diagnostic strategies and patient management for rare liver tumors.
