[Human chorionic prealbumin: its identification, physicochemical properties and detection in the blood serum in...

Human chorionic prealbumin (HCPA) was immunochemically identified and isolated in pure form from immature placenta, particularly, from chorion. Comparative immunodiffusion analysis shows that HCPA differs from the known placenta-specific proteins. HCPA is a glycoprotein with MW about 100 KD determined by gel-filtration and 45 KD by SDS polyacrylamide gel electrophoresis. By immunodiffusion HCPA was not found in fetal and adult tissues and in biological fluids. HCPA was discovered in patients with trophoblastic diseases but was not revealed in other oncological situations.