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The Tribble with APL: A New Road to Therapy

Ruaidhrí Carmody1, Karen Keeshan2

  • 1Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.

Cancer Cell
|May 10, 2017
PubMed
Summary

Researchers discovered the pseudokinase stress protein TRIB3 is crucial in acute promyelocytic leukemia (APL) progression and treatment resistance. Targeting the TRIB3 and PML-RARα interaction offers a new therapeutic strategy for APL.

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