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In Vivo Confocal Microscopy: A Standard Operating Procedure for the Detection of Demodex Mites at the Eyelid Margin
Published on: July 3, 2025
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Demodicosis in Pediatric Cancer
Jenneke E van Atteveld1, Marlies de Graaf, Martine van Grotel
1*Princess Máxima Center for Pediatric Oncology †Department of Dermatology, University Medical Center-Wilhelmina Children's Hospital, Utrecht, The Netherlands.
Journal of Pediatric Hematology/Oncology
|May 10, 2017
Summary
Demodicosis, a rare skin condition, can manifest as facial papulopustular eruptions in children undergoing cancer treatment. Early consideration of demodicosis is crucial for timely and effective management in pediatric cancer patients.
Area of Science:
- Dermatology
- Pediatric Oncology
- Infectious Diseases
Background:
- Demodicosis is a rare parasitic skin infestation.
- It predominantly affects immunocompromised individuals.
- Facial papulopustular eruptions can mimic other conditions.
Observation:
- A pediatric patient with T-cell non-Hodgkin lymphoma developed a facial papulopustular eruption.
- The eruption was resistant to treatments for infectious diseases.
- Topical metronidazole led to complete resolution of the eruption.
Findings:
- A systematic review of pediatric cancer patients revealed a strong association between demodicosis and lymphoreticular malignancies.
- Demodicosis commonly occurs during maintenance chemotherapy phases.
- Antibiotic-resistant facial papulopustular eruptions in this population warrant consideration of demodicosis.
Implications:
- Demodicosis should be considered in the differential diagnosis of facial eruptions in pediatric cancer patients.
- Prompt diagnosis and treatment of demodicosis can prevent delayed management of underlying conditions.
- This highlights the importance of recognizing opportunistic infections in immunocompromised children.
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