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Published on: June 6, 2025
Elevated ACKR2 expression is a common feature of inflammatory arthropathies
Helen M Baldwin1, Mark D Singh1, Veronica Codullo1
1Institute of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Atypical chemokine receptor 2 (ACKR2) is elevated in inflammatory arthropathies. This finding suggests ACKR2 plays a common role in inflammatory pathologies, offering potential therapeutic targets.
Area of Science:
- Immunology
- Molecular Biology
- Pathology
Background:
- Chemokines orchestrate leukocyte accumulation in inflammation.
- Atypical chemokine receptors fine-tune inflammatory responses.
- Atypical chemokine receptor 2 (ACKR2) scavenges inflammatory CC-chemokines, aiding response resolution.
Purpose of the Study:
- To investigate ACKR2 expression in common arthropathies.
- To understand ACKR2's role in inflammatory joint diseases.
Main Methods:
- Quantitative PCR (qPCR) and immunohistochemistry were used to measure ACKR2 expression.
- Circulating cytokine and chemokine levels were assessed via multiplexing assays in patient plasma.
Main Results:
- ACKR2 expression was increased on peripheral blood cells, synovial leukocytes, and stromal cells in arthropathies.
- Elevated ACKR2 on blood leukocytes correlated with circulating IL-6 and hepatocyte growth factor.
- Synovial ACKR2 expression coincided with lymphocyte aggregates and inflammatory chemokine sites.
Conclusions:
- Increased ACKR2 expression is evident across various arthropathies.
- Elevated ACKR2 is proposed as a common feature of inflammatory pathologies.
- ACKR2 represents a potential therapeutic target for inflammatory diseases.
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