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Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Psychological and Sociocultural Causes of Schizophrenia01:29

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Depression: Overview01:18

Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Long-term Depression01:03

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
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Long-term Depression01:05

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term, durable, absolute Psoriasis Area and Severity Index and health-related quality of life improvements with risankizumab treatment: a post hoc integrated analysis of patients with moderate-to-severe plaque psoriasis.

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Related Experiment Video

Updated: Mar 2, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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Psoriasis, Depression, and Suicidality.

M N Nicholas1, M Gooderham2

  • 1University of Toronto, Faculty of Medicine, Toronto, ON, Canada.

Skin Therapy Letter
|May 10, 2017
PubMed
Summary

Psoriasis patients, especially younger ones or those with severe disease, face higher risks of depression and suicidality. Early identification and optimal treatment are key to managing these mental health impacts.

Area of Science:

  • Dermatology
  • Psychiatry
  • Public Health

Background:

  • Psoriasis is a chronic skin condition impacting patient well-being and quality of life.
  • The association between psoriasis, depression, and suicidality is often underestimated by the public.
  • Understanding mental health effects and identifying at-risk individuals are crucial.

Purpose of the Study:

  • To explore the impact of psoriasis on mental health.
  • To identify risk factors for depression and suicidality in psoriasis patients.
  • To highlight the need for improved treatment strategies.

Main Methods:

  • Review of risk factors including age, gender, and disease severity in psoriasis.
  • Analysis of the correlation between these factors and mental health outcomes.

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  • Assessment of current treatment patterns and their effectiveness.

    • Main Results:

    • Younger age and greater psoriasis severity are significantly associated with increased depression and suicidality.
    • Despite effective treatments, undertreatment of psoriasis and its associated mental health issues is prevalent.
    • Specific patient subgroups are at higher risk for psychiatric comorbidities.

    Conclusions:

    • Age and disease severity are critical factors in identifying psoriasis patients at risk for depression and suicidality.
    • Optimizing psoriasis treatment can alleviate the associated psychiatric burden.
    • Targeted interventions for high-risk patients are essential for comprehensive care.