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Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis
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Ruta chalepensis L. (Rutaceae) leaf extract: chemical composition, antioxidant and hypoglicaemic activities.

M R Loizzo1, T Falco1, M Bonesi1

  • 1a Department of Pharmacy , Health Sciences and Nutrition, University of Calabria , Rende (CS) , Italy.

Natural Product Research
|May 11, 2017
PubMed
Summary

Ruta chalepensis leaf extract, rich in hesperidin and rutin, demonstrates significant antioxidant and hypoglycemic properties. This suggests its potential as a beneficial ingredient for healthy food products.

Keywords:
HPLC analysisRuta chalepensisantioxidant activityhypoglycaemic activityleaves

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Nutritional Science

Background:

  • Ruta chalepensis L. (Rutaceae) is a plant species with traditional uses.
  • Understanding its chemical composition and biological activities is crucial for validating its applications.

Purpose of the Study:

  • To investigate the chemical profile of Ruta chalepensis leaf extract.
  • To evaluate its antioxidant and hypoglycemic properties.

Main Methods:

  • Chemical profile analysis.
  • Antioxidant assays: 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene bleaching, metal chelating activity.
  • Hypoglycemic potential assessment via carbohydrate-hydrolysing enzymes inhibition (α-amylase, α-glucosidase).

Main Results:

  • Extract contains high levels of hesperidin (591.9 mg/g) and rutin (266.7 mg/g).
  • Demonstrated significant antioxidant activity, protecting against lipid peroxidation (IC50 = 16.9 μg/mL).
  • Showed concentration-dependent inhibition of α-amylase (IC50 = 69.0 μg/mL) and α-glucosidase.

Conclusions:

  • Ruta chalepensis leaf extract possesses notable antioxidant and hypoglycemic effects.
  • The presence of hesperidin and rutin contributes to these activities.
  • Results support the incorporation of Ruta chalepensis leaves into healthy food formulations.