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Updated: Mar 2, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium
Debajyoti Basak1, Sucheta Sridhar2, Amal K Bera2
1Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.
Abstract:
Synthetic channels or pores that are easy to synthesize, stable and cation-selective are extremely attractive for the development of therapeutics and materials. Herein, we report a pore developed from a small tetrapeptide scaffold that shows a preference for sodium over lithium/potassium. The sodium selectivity is attributed to the appended oligoether tail at the C-terminus. A peptide dimer is proposed as the predominant cation-transporting pore. Such pyridine containing stable pores can be potentially utilized for the pH modulated ion transport.
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