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Related Experiment Video

Updated: Mar 2, 2026

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

Published on: July 27, 2019

The function of LINE-1-encoded reverse transcriptase in tumorigenesis.

Zhong-jie Ye¹, Qi-peng Liu¹, Shan Cen¹

¹Department of Immunology, Institute of Medicinal Biotechnology, Chinese academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Yi Chuan = Hereditas

|May 11, 2017

Summary

The LINE-1 reverse transcriptase, crucial for human genome transposition, impacts cancer progression. Inhibiting this enzyme may offer new strategies for cancer diagnosis and drug development.

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RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

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Related Experiment Videos

Last Updated: Mar 2, 2026

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

Published on: July 27, 2019

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level

Published on: April 23, 2016

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

Area of Science:

Genetics
Molecular Biology
Cancer Research

Background:

LINE-1 (Long Interspersed Nuclear Element-1) is the most abundant human transposon, comprising 17% of the genome.
LINE-1 encodes a reverse transcriptase essential for its transposition and implicated in various physiological and pathological processes, including cancer.

Purpose of the Study:

To review recent evidence on the role of LINE-1 reverse transcriptase in tumorigenesis.
To elucidate how LINE-1 reverse transcriptase influences cancer by shaping non-coding RNA transcriptomes.

Main Methods:

Literature review of recent studies on LINE-1 reverse transcriptase and cancer.
Analysis of the impact of LINE-1 reverse transcriptase on non-coding RNA profiles in cancer.

Main Results:

Inhibition of LINE-1 reverse transcriptase activity halts tumor progression.
LINE-1 reverse transcriptase inhibition can restore cancer cell differentiation and alter global transcription.

Conclusions:

LINE-1 reverse transcriptase plays a significant role in cancer development.
Targeting LINE-1 reverse transcriptase may provide novel avenues for cancer diagnosis and therapeutic strategies.