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Evidence for EpCAM and Cytokeratin Expressing Epithelial Cells in Normal Human and Murine Blood and Bone Marrow
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Epithelial cells reject abnormal neighbors.

Annalisa M VanHook1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|May 11, 2017
PubMed
Summary

Normal epithelial cells actively alter the metabolism of nearby cancer cells. This metabolic reprogramming helps expel transformed cells from the epithelial tissue, preventing tumor formation.

Area of Science:

  • Cell biology
  • Cancer research
  • Metabolic pathways

Background:

  • Epithelial tissues form barriers crucial for organ function.
  • Disruption of epithelial integrity is a hallmark of cancer progression.
  • Cell-cell interactions play a role in maintaining tissue homeostasis.

Purpose of the Study:

  • To investigate the metabolic interplay between normal epithelial cells and adjacent transformed cells.
  • To determine if normal cells can induce metabolic changes in transformed cells.
  • To understand the mechanism by which normal cells influence the behavior of transformed cells within an epithelium.

Main Methods:

  • Co-culture systems of normal and transformed epithelial cells.
  • Metabolomic analysis to profile cellular metabolic states.

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  • Live-cell imaging to observe cell behavior and expulsion.
  • Genetic manipulation to identify key metabolic pathways involved.

    • Main Results:

    • Normal epithelial cells induced significant metabolic alterations in neighboring transformed cells.
    • These metabolic changes were associated with the expulsion of transformed cells from the epithelial layer.
    • Specific metabolic pathways were identified as critical mediators of this cellular response.

    Conclusions:

    • Normal epithelial cells possess a mechanism to maintain tissue integrity by metabolically influencing and expelling transformed cells.
    • This finding highlights a novel form of intercellular communication in cancer prevention.
    • Targeting these metabolic interactions could offer new therapeutic strategies against early-stage cancer.