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In veterinary trials reporting and communication regarding randomisation procedures is suboptimal.

N Di Girolamo1, M A Giuffrida2, A L Winter3

  • 1EBMVet, Via Sigismondo Trecchi, 20, Cremona CR 26100, Italy.

The Veterinary Record
|May 11, 2017
PubMed
Summary
This summary is machine-generated.

Randomisation reporting in veterinary trials is poor, with many non-random methods used and mechanisms often not reported. Improving adherence to guidelines like CONSORT is crucial for veterinary evidence quality.

Keywords:
Clinical trialsEvidence-based medicineclinical epidemiologymethodologyrandomisationrandomised controlled trials

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Area of Science:

  • Veterinary Medicine
  • Clinical Trials
  • Research Methodology

Background:

  • Randomisation is key to unbiased clinical trials.
  • The quality of randomisation reporting in veterinary literature requires evaluation.
  • Adherence to reporting guidelines like CONSORT is essential for research integrity.

Purpose of the Study:

  • To assess the quality of randomisation mechanisms reported in veterinary clinical trials.
  • To identify the prevalence of non-random methods and inadequate reporting of randomisation procedures.
  • To explore trialists' willingness to improve randomisation reporting.

Main Methods:

  • Extraction of 'randomised' trials from five leading veterinary journals in 2013.
  • Evaluation of random sequence generation, method, and type of randomisation by blinded investigators.
  • Contacting trialists via email to assess willingness to discuss and improve randomisation reporting.

Main Results:

  • 7% of 'randomised' trials used non-random methods.
  • 49% of trials failed to report any randomisation mechanism.
  • Only 12.3% reported both required CONSORT items for randomisation.
  • 34.2% of contacted trialists were willing to respond, with limited clarification achieved.

Conclusions:

  • Significant deficiencies exist in randomisation reporting in veterinary trials.
  • Improved adherence to CONSORT guidelines and better communication are vital.
  • Enhancing randomisation practices will improve the quality of veterinary evidence and reduce research waste.