Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

4.2K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.2K
RNA-seq03:21

RNA-seq

12.3K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
12.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Five genome sequences of bacterial environmental isolates from Gilkey Glacier, Juneau Icefield, Alaska.

Microbiology resource announcements·2026
Same author

Spatial remodeling of bone marrow architecture defines tissue-state signatures of disease activity and therapeutic response in myelodysplastic neoplasms.

Leukemia·2026
Same author

Targeting macrophage ferritin heavy chain mitigates ferroptosis and lung injury in experimental acute respiratory distress syndrome.

Nature communications·2026
Same author

Derivation of elephant induced pluripotent stem cells.

Nature methods·2026
Same author

Shotgun metagenomic dataset of surface microbiomes at a train station in Shinagawa, Tokyo.

BMC genomic data·2026
Same author

Sustained Chlorination of Hospital Surfaces Restructures the Microbiome and Virome and Diversifies Resistance Genes.

Environmental science & technology·2026
Same journal

Single-cell evidence for PANoptosome complexes.

Nature reviews. Molecular cell biology·2026
Same journal

Reply to 'Single-cell evidence for PANoptosome complexes'.

Nature reviews. Molecular cell biology·2026
Same journal

Plucking cellular ribosomes with Ribo-Tweezer.

Nature reviews. Molecular cell biology·2026
Same journal

COPII meets autophagy at the ER membrane.

Nature reviews. Molecular cell biology·2026
Same journal

Diapause presses pause on life's developmental and ageing clock.

Nature reviews. Molecular cell biology·2026
Same journal

Histone acetylation at the dawn of gene regulation.

Nature reviews. Molecular cell biology·2026
See all related articles

Related Experiment Video

Updated: Mar 2, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

14.1K

Charting the unknown epitranscriptome.

Eva Maria Novoa1,2, Christopher E Mason3, John S Mattick1,2

  • 1Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

Nature Reviews. Molecular Cell Biology
|May 11, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed new methods to map RNA modifications across the genome. This work aims to uncover the distribution, location, and dynamics of these crucial RNA elements.

More Related Videos

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
10:41

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

Published on: May 9, 2017

9.7K
iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
10:45

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

59.4K

Related Experiment Videos

Last Updated: Mar 2, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

14.1K
Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
10:41

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

Published on: May 9, 2017

9.7K
iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
10:45

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

59.4K

Area of Science:

  • Molecular Biology
  • Genomics
  • Biochemistry

Background:

  • RNA modifications impact RNA structure, function, and cellular processes.
  • The genomic distribution and biological roles of most RNA modifications are largely unknown.

Purpose of the Study:

  • To develop and apply novel techniques for the systematic study of RNA modifications.
  • To investigate the distribution, location, and dynamics of RNA modifications genome-wide.

Main Methods:

  • Phage display antibody technology for specific RNA modification recognition.
  • Direct sequencing through nanopores for high-throughput analysis.

Main Results:

  • Established a framework for interrogating RNA modifications.
  • Enabled systematic analysis of RNA modification patterns.

Conclusions:

  • New technologies facilitate comprehensive study of RNA modifications.
  • Understanding RNA modification dynamics is key to elucidating their cellular roles.