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Obesity, bariatric surgery and oxidative stress
Roberta Cattaneo Horn1, Gabriela Tassotti Gelatti2, Natacha Cossettin Mori1
1Professor in the Pharmaceutic Faculty, Universidade de Cruz Alta (Unicruz), Cruz Alta, RS, Brazil.
Revista Da Associacao Medica Brasileira (1992)
|May 11, 2017
Summary
Bariatric surgery significantly reduces oxidative stress and tissue damage in obese women by lowering lipid peroxidation and protein carbonylation. Weight loss and vitamin supplementation post-surgery contribute to improved antioxidant markers.
Area of Science:
- Biochemistry
- Endocrinology
- Surgical Research
Background:
- Obesity is linked to increased oxidative stress and tissue damage due to reactive oxygen species.
- Effective weight reduction strategies are crucial for mitigating obesity-related health complications.
Purpose of the Study:
- To evaluate the impact of bariatric surgery on oxidative and antioxidant markers in obese women.
- To determine if these markers change post-surgery, potentially reducing oxidative damage.
Main Methods:
- Assessed 16 morbidly obese women pre- and post-bariatric surgery (180 days).
- Included 16 non-obese women as a control group.
- Measured plasma levels of thiobarbituric acid-reactive substances, carbonylated proteins, reduced glutathione, and ascorbic acid.
Main Results:
- Pre-surgical obese women exhibited higher lipid peroxidation and protein carbonylation than controls and post-surgical patients.
- Reduced glutathione levels were elevated pre-surgery and decreased post-surgery.
- Ascorbic acid levels were lower in pre-surgical obese women compared to controls and post-surgical patients.
Conclusions:
- Obesity elevates oxidative stress, evidenced by altered oxidant and antioxidant markers.
- Bariatric surgery, coupled with weight loss and potential vitamin supplementation, effectively reduces cellular oxidation and subsequent tissue damage.
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