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Angiolymphatic invasion as a prognostic fator in resected N0 pancreatic adenocarcinoma
Ricardo Vitor Silva de Almeida1, Adhemar Monteiro Pacheco1, Rodrigo Altenfelder Silva1
1Discipline of Surgery of the Pancreas and Biliary System, Department of Surgery, Brotherhood of Santa Casa de São Paulo, São Paulo, SP, Brasil.
Background:
Pancreatic adenocarcinoma remains one of the worst digestive cancers. Surgical resection is the main target when treating a patient with curative intent.
Aim:
To assess angiolymphatic invasion as a prognostic factor in resected pN0 pancreatic cancer.
Methods:
Thirty-eight patients were submitted to pancreatoduodenectomy due to head pancreatic cancer. Tumor size, margins, lymph nodes, pTNM staging, angiolymphatic and perineural invasion were described in the pathologists' reports.
Results:
Most patients were female. Overall median survival was 13 months. Gemcitabine was the regimen of choice for chemotherapy in selected patients; however, it did not improve overall survival. pR0 resection had better survival compared with pR1. Within the pN0 group, survival was significantly better in patients without angiolymphatic invasion.
Conclusion:
Angiolymphatic invasion in N0 pancreatoduodenectomy can be demonstrated by the Hematoxylin-Eosin stain and may predict a poor prognosis factor for those patients.
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