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Related Experiment Videos

Hepatic Na,K-ATPase development in the rat.

L F Duffy1, P I Karl, F Daum

  • 1Department of Pediatrics, North Shore University Hospital, Manhasset, NY 11030.

Journal of Pediatric Gastroenterology and Nutrition
|November 1, 1988
PubMed
Summary

Hepatic sodium-potassium ATPase (Na,K-ATPase) enzyme activity increases significantly from fetal development to young adulthood in rats. Glucocorticoids can induce this enzyme

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Area of Science:

  • Biochemistry
  • Developmental Biology
  • Physiology

Background:

  • The sodium-potassium ATPase (Na,K-ATPase) is crucial for cellular function.
  • Understanding its developmental trajectory in the liver is key to comprehending hepatic maturation.

Purpose of the Study:

  • To investigate the ontogeny of Na,K-ATPase activity in rat liver.
  • To examine the influence of glucocorticoids on hepatic Na,K-ATPase during development.

Main Methods:

  • Assessed Na,K-ATPase activity in Sprague-Dawley rat hepatic tissue across various developmental stages (fetal to adult).
  • Measured enzyme activity per gram of tissue and per milligram of protein.
  • Investigated glucocorticoid induction using cortisone acetate in 11-day-old rats.

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Main Results:

  • Hepatic Na,K-ATPase activity per gram of tissue showed a marked increase from fetal life, reaching adult levels by 21 days.
  • Enzyme activity expressed per milligram of protein displayed a less pronounced developmental pattern.
  • Cortisone acetate administration significantly induced Na,K-ATPase specific activity in young rats.

Conclusions:

  • Hepatic Na,K-ATPase activity follows a distinct developmental pattern, increasing substantially during postnatal maturation.
  • The inducibility of Na,K-ATPase by glucocorticoids suggests hormonal regulation plays a role in its ontogeny.
  • This developmental pattern may influence the maturation of sodium-dependent hepatic transport processes, including bile salt transport.