[Effect of estrogens and thyroid hormones on the development of isoprenaline-induced myocardiodystrophy]

An experimental study in female rats demonstrated that hyperestrogenemia (unlike hypoestrogenemia or hyperthyroidism) enhanced the myocardial necrotic effect of isoprenaline. There was no clear-cut correlation between the extent of myocardial damage and cAMP phosphodiesterase activity.