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Mood disorders in adult asthma phenotypes
Marina Labor1,2, Slavica Labor1,2, Iva Jurić3
1a Department of Pulmonology , University Hospital Center Osijek , Osijek , Croatia.
Summary
Asthma phenotypes, including allergic and late-onset asthma, are linked to anxiety and depression. These mood disorders significantly impact asthma control, highlighting the need for phenotype-specific management strategies.
Area of Science:
- Pulmonary Medicine
- Psychiatry
- Clinical Research
Background:
- High comorbidity of mood disorders (anxiety/depression) is observed in asthma patients.
- Asthma heterogeneity, characterized by distinct phenotypes, suggests varying associations with mood disorders.
- Understanding these associations is crucial for effective asthma management.
Purpose of the Study:
- To investigate the association between specific asthma phenotypes and the presence of anxiety and/or depression.
- To evaluate the impact of these mood disorders on asthma control across different phenotypes.
Main Methods:
- A cross-sectional study involving 201 adult asthma outpatients.
- Assessment included physical examination, medical history, validated mood disorder and asthma control questionnaires, lung function tests, and fractional exhaled nitric oxide measurements.
- Asthma phenotypes were identified using cluster analysis, with multivariate analysis employed to determine associations.
Main Results:
- Five asthma phenotypes were identified: allergic asthma (AA), aspirin-exacerbated respiratory disease (AERD), late-onset asthma (LOA), obesity-associated asthma (OAA), and respiratory infections-associated asthma (RIAA).
- Anxiety was significantly associated with LOA and hypertension.
- Depression and comorbid anxiety/depression showed significant associations with AA, RIAA, hypertension, and asthma control questionnaire (ACQ) scores.
Conclusions:
- Mood disorders are significantly linked to specific asthma phenotypes: allergic asthma (AA), late-onset asthma (LOA), and infection-associated asthma (RIAA).
- Comorbid hypertension and poorer asthma control are also associated with mood disorders in these asthma phenotypes.
- These findings underscore the importance of considering asthma phenotypes and comorbidities in managing mood disorders and improving asthma control.
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