How Plastic Are Pericytes?
Related Experiment Video
Updated: Mar 2, 2026

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
Published on: May 26, 2017
Alexander Birbrair1,2,3, Isabella da Terra Borges1, Isadora Fernandes Gilson Sena1
11 Department of Pathology, Federal University of Minas Gerais , Belo Horizonte, MG, Brazil .
Abstract:
Pericytes are defined by both their anatomical location and molecular markers. Numerous publications have reported their role as stem cells, contributing to the formation of tissues other than blood vessels. However, using cell-lineage tracing in a new transgenic mouse model, a recent study shows that in the context of aging and some pathologies, Tbx18+ pericytes do not function as stem cells in vivo. This study challenges the current view that pericytes can differentiate into other cells and reopen questions about their plasticity. This emerging knowledge is important not only for our understanding of development but may also inform treatments for diseases.
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