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Related Experiment Video

Updated: Mar 2, 2026

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
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How Plastic Are Pericytes?

Alexander Birbrair1,2,3, Isabella da Terra Borges1, Isadora Fernandes Gilson Sena1

  • 11 Department of Pathology, Federal University of Minas Gerais , Belo Horizonte, MG, Brazil .

Stem Cells and Development
|May 12, 2017
PubMed
Summary

New research using transgenic mice reveals that Tbx18+ pericytes do not act as stem cells in aging and diseased conditions. This finding challenges the established view of pericyte plasticity and differentiation potential in vivo.

Keywords:
pericytesplasticityregenerationstem cells

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Area of Science:

  • Cell biology
  • Developmental biology
  • Stem cell research

Background:

  • Pericytes are traditionally identified by location and molecular markers.
  • Previous studies suggested pericytes possess stem cell properties, contributing to non-vascular tissue formation.
  • The plasticity and in vivo differentiation capacity of pericytes remain areas of active investigation.

Purpose of the Study:

  • To investigate the in vivo stem cell function of Tbx18+ pericytes.
  • To challenge the prevailing notion of pericyte differentiation potential.
  • To clarify the role of pericytes in aging and pathological contexts.

Main Methods:

  • Utilized a novel transgenic mouse model.
  • Employed cell-lineage tracing techniques.
  • Examined pericyte behavior in aging and disease models.

Main Results:

  • Tbx18+ pericytes demonstrated a lack of stem cell function in vivo.
  • Evidence suggests these pericytes do not differentiate into non-vascular tissues under tested conditions.
  • The study provides new insights into pericyte behavior during aging and disease.

Conclusions:

  • The findings challenge the established view of pericyte stemness and plasticity.
  • Re-evaluates the contribution of pericytes to tissue regeneration and development.
  • Informs future research on pericyte-related therapies and disease mechanisms.