[Effect of left ventricular hypertrophy and deformation on cardiac function in patients with uremia cardiomyopathy by...

To evaluate the effect of left ventricular hypertrophy and deformation on cardiac function in patients with uremic cardiomyopathy (UCM) by using the technology of two dimensional speckle tracking imaging (2D-STI).
 Methods: A total of 67 UCM patients were randomly divided into the normal cardiac function group (subgroup A, 32 cases) and the abnormal cardiac function group (subgroup B, 35 cases) according to the New York Heart Association points (NYHA-P). A total of 30 healthy subjetcs served as the control group. Parameters including left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI), left ventricular spherical index (LVSI), left ventricular myocardial mean radial strain (MRS), mean radial strain rate (MRSR), mean longitudinal strain (MLS), local systolic twist angle (STA), and mitral annulus maximum displacement (TMAD) were detected.
 Results: MLS, MRS, MRSR, LVSI, STA and TMAD in the Group A and Group B were lower than that in the control group (P<0.05), and LVMI in the Group A and Group B was increased than those in the control group (P<0.05); LVEF, MLS, MRS, MRSR, LVSI and STA in the Group B was decreased than that in the Group A (P<0.05). MLS in the Group A and B were positively correlated with LVEF and LVSI, but negatively correlated with LVMI. Using the point of 14.10% for MLS to evaluate UCM patients with NYHA-P>4 points, the sensitivity, the specificity and Yuedden index were 90.5%, 71% and 0.585, respectively. STA in UCM patients were lower than that in the control (P<0.05).
 Conclusion: 2D-STI possesses a unique advantage in detecting left ventricular strain and strain rate on left ventricular regional function in UCM with left ventricular hypertrophy and ventricular deformation. There is no direct correlation between the left ventricular hypertrophy and ventricular deformation, but the ventricular hypertrophy and deformation are correlated with regional cardiac function and clinical cardiac function. Left ventricular regional dysfunction may occur before cardiac hypertrophy and deformation.