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Updated: Mar 2, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
[Advance in glutathione S-transferase kappa 1]
1Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China.
Abstract:
Glutathione S-transferase kappa 1 (GSTK1) is a key regulator for adiponectin secretion and multimerization. In Caenorhabditis elegans, GSTK1 is involved in energy production and lipid metabolism. Meanwhile, the GSTK1 level is negatively correlated with obesity. It may alleviate the endoplasmic reticulum stress-mediated downregulation of adiponectin. Moreover, a polymorphism in human GSTK1 promoter is related with insulin secretion and fat deposition. Therefore, GSTK1 might be a novel target for the treatment of insulin resistance and the relevant metabolic diseases.
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