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Updated: Mar 2, 2026
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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
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Radiosurgery for liver metastases. A single institution experience
Beatriz Amendola1, Marco Amendola1, Jesús M Blanco1
1Innovative Cancer Institute, South Miami, FL 33143, United States.
Summary
Stereotactic body radiation therapy (SBRT) using radiosurgery is a safe and effective treatment for liver metastases. This approach offers good local control and minimal toxicity for patients with one or multiple liver lesions.
Area of Science:
- Radiation oncology
- Medical physics
- Hepatobiliary oncology
Background:
- Increasing interest in stereotactic body radiation therapy (SBRT) for liver metastases.
- SBRT as an alternative to interventional procedures for liver disease.
Purpose of the Study:
- To report initial results of radiosurgery for liver metastases.
- Evaluate the safety and efficacy of SBRT in treating liver metastases.
Main Methods:
- 36 LINAC-based radiosurgeries using VMAT performed between 2008 and 2015.
- Treated 27 patients with liver metastases from 10 primary sites.
- Doses ranged from 21 Gy to 60 Gy in 1-5 fractions, respecting normal tissue constraints.
Main Results:
- Median survival of 9 months; 80% survived over 6 months.
- Local recurrence-free survival median of 14 months.
- Excellent safety profile with only Grade 2 toxicity in 1 patient; no Grade 3-4 toxicity.
Conclusions:
- SBRT with radiosurgery is safe and effective for liver metastases.
- Effective for treating single or multiple liver lesions.
- Emphasizes the importance of respecting normal liver tissue constraints.
