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Optimal Solubility of Diclofenac β-Cyclodextrin in Combination with Local Anaesthetics for Mesotherapy Applications

Giuseppe Tringali1, Pierluigi Navarra1

  • 1Institute of Pharmacology, Catholic University Medical School, Rome, Italy.

Evidence-Based Complementary and Alternative Medicine : Ecam
|May 12, 2017
PubMed

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Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
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One of the advantages of...
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