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Published on: May 9, 2022
Effect of Combined Therapy Using Diode Laser and Photodynamic Therapy on Levels of IL-17 in Gingival Crevicular Fluid
Abhishek Mistry1, Richard Pereira1, Vineet Kini1
1Department of Periodontics, Mahatma Gandhi Mission's Dental College and Hospital, Junction of NH4 and Sion-Panvel Expressway, Kamothe, Navi Mumbai- 410209, India.
Abstract:
Introduction: The aim of this study was to evaluate the efficacy of combination therapy of diode laser and photodynamic therapy (PDT) as an adjunct to scaling and root planing (SRP) on interleukin-17 (IL-17) levels in gingival crevicular fluid (GCF) in patients with chronic periodontitis. Methods: Thirty subjects with chronic periodontitis were included. All teeth received periodontal treatment comprising of SRP. Using a split mouth study design, the test group was additionally treated with a combination therapy of diode laser and PDT. GCF was collected to evaluate IL-17 levels at baseline and 3 months. Results: There was no difference in baseline values for levels of IL-17 in GCF in the test group and the control group. A significant decrease in GCF levels of IL-17 was observed in both treatment groups 3 months after treatment (P < 0.001). However, the treatment groups showed no significant difference (P > 0.05). Conclusion: Based on the results of the present study it was concluded that, GCF levels of IL-17 changed significantly after treatment regardless of treatment modality.
