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Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
Published on: November 17, 2023
The Histopathological Parameters Affecting Biochemical Recurrence in Radical Prostatectomies
Yelda Dere1, Aysegu Aksoy Altinboga2, Kaan Bal3
1Department of Pathology, Mugla Sitki Kocman University, Faculty of Medicine, Mugla, Turkey.
Objective:
To determine the relationship between biochemical recurrence and other histopathological factors in prostate cancer.
Study Design:
Analytical study.
Place And Duration Of Study:
Pathology and Urology Departments, Izmir Ataturk Training and Research Hospital, between 2001 - 2013.
Methodology:
117 cases diagnosed with prostatic adenocarcinoma and treated by radical prostatectomy were reviewed retrospectively for histopathological features; whereas, other prognostic findings were noted. PSA levels and many other histopathological parameters were assessed in order to put forth their effect on biochemical recurrence.
Results:
PSA level (p<0.001), tumor volume (p<0.001), Gleason score (p<0.001), extraprostatic extension (p<0.001), perineural invasion (p<0.001), ganglion involvement (p=0.040), vascular invasion (p<0.001), positive surgical margins (p<0.001), presence of tertiary pattern (p=0.004) and the involvement of the seminal vesicles (p<0.001) were found to be statistically related to the pathological stage. Age, perineural invasion, high grade tertiary pattern, intraluminal mucin, collagenous micronodules and foamy cytoplasmic changes were unrelated to recurrence.
Conclusion:
Histopathological features can be helpful in predicting prognosis in prostatic adenocarcinomas. However some of the histopathological factors such as intraluminal mucin and foamy cytoplasmic changes may not reflect high recurrence.
