Tuberculosis mortality in Brazilian capitals, 2008-2010

Area of Science:

• Public Health
• Epidemiology
• Social Determinants of Health

Background:

• Tuberculosis remains a significant global health challenge, particularly in Brazil.
• Understanding the socio-demographic and health factors influencing tuberculosis mortality is crucial for targeted interventions.

Purpose of the Study:

• To investigate the association between tuberculosis mortality and various socio-demographic and health indicators.
• To analyze these associations in the capitals of Brazilian states and the Federal District.

Main Methods:

• Ecological study design analyzing tuberculosis mortality data from 2008-2010.
• Utilized Pearson correlation and multiple linear regression to assess 16 independent variables across three blocks.
• Outcome variable: standardized coefficient of tuberculosis mortality.

Main Results:

• A total of 4,744 tuberculosis deaths were recorded (2.7 per 100,000 inhabitants).
• Significant associations (p<0.10) were found with: income inequality (Gini index), proportion of migrants, poverty among Black individuals, and tuberculosis/HIV coinfection.
• Specific coefficients (β) and confidence intervals (95%CI) were reported for each associated indicator.

Conclusions:

• Tuberculosis mortality rates are higher in Brazilian capitals exhibiting greater income inequality.
• Increased migration, poverty within the Black population, and the prevalence of tuberculosis/HIV coinfection are associated with elevated tuberculosis mortality.
• These findings highlight the impact of social determinants on tuberculosis outcomes.