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A Syngeneic Pancreatic Cancer Mouse Model to Study the Effects of Irreversible Electroporation
Published on: June 8, 2018
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Recurrence patterns following irreversible electroporation for hepatic malignancies.
Russell C Langan1, Debra A Goldman2, Michael I D'Angelica1
1Department of Surgery, Hepatopancreatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Journal of Surgical Oncology
|May 12, 2017
Summary
Irreversible electroporation (IRE) shows low local recurrence rates for small hepatic tumors. This ablative therapy is effective for lesions unsuitable for surgery or thermal ablation.
Area of Science:
- Oncology
- Surgical Oncology
- Medical Devices
Background:
- Irreversible electroporation (IRE) is a novel ablative therapy for peri-vascular lesions.
- Long-term outcome data for IRE in hepatic malignancies is limited.
Purpose of the Study:
- To evaluate the long-term outcomes of irreversible electroporation (IRE) for hepatic malignancies.
- To determine local recurrence (LR) rates and associated risk factors after IRE treatment.
Main Methods:
- Retrospective analysis of patients undergoing open IRE for hepatic malignancies (January 2011 - June 2015).
- Local ablation-zone recurrence (LR) assessed via cross-sectional imaging.
- Cumulative incidence of LR calculated; competing risks regression used to identify associated factors.
Main Results:
- 77 lesions in 40 patients treated, predominantly colorectal origin (74%), median tumor size 1.3 cm.
- Median follow-up of 25.7 months; 13.4% local recurrence rate (10 lesions in 9 patients).
- Ablation zone size and body mass index were significant factors associated with LR.
Conclusions:
- Irreversible electroporation (IRE) demonstrates low local recurrence rates for well-selected, small hepatic tumors.
- IRE is a valuable technique for lesions in locations unsuitable for resection or thermal ablation.
