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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
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Scaffold Diversity from N-Acyliminium Ions.
Peng Wu1,2,3,4,5,6, Thomas E Nielsen1,2,7
1Department of Chemistry, Technical University of Denmark , Kongens Lyngby DK-2800, Denmark.
Chemical Reviews
|May 12, 2017
Summary
N-acyliminium ion cyclization reactions are versatile tools for synthesizing complex molecular structures. This review covers advancements in using these reactions to build diverse chemical scaffolds from 2004 to 2015.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- N-acyliminium ions are key reactive intermediates in organic synthesis.
- These ions facilitate the formation of carbon-carbon and carbon-heteroatom bonds.
- Intramolecular cyclization reactions involving N-acyliminium ions are crucial for constructing complex molecular architectures.
Purpose of the Study:
- To provide a comprehensive overview of N-acyliminium ion cyclization reactions.
- To highlight the assembly of structurally diverse scaffolds using these methods.
- To cover literature published between 2004 and 2015.
Main Methods:
- Review of scientific literature focusing on N-acyliminium ion chemistry.
- Analysis of cyclization reactions involving various N-acyliminium ion precursors.
- Categorization of synthesized scaffolds based on structural complexity.
Main Results:
- Demonstration of N-acyliminium ion cyclizations for creating bicyclic, polycyclic, and natural-product-like compounds.
- Compilation of diverse synthetic strategies employing these reactive intermediates.
- Identification of trends and advancements in the field over a 12-year period.
Conclusions:
- N-acyliminium ion cyclization represents a powerful and adaptable strategy in synthetic organic chemistry.
- These reactions are instrumental in accessing a wide array of complex molecular scaffolds.
- The reviewed literature showcases significant progress in the application of N-acyliminium ion chemistry for molecular construction.
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