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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia
Laura Ehrlich1, Alice Hoeller1, Michaela Golic1,2
1a Department of Obstetrics , Campus Virchow-Clinic, Charite´ University Medicine , Berlin , Germany.
Objective:
To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF).
Methods:
Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity.
Results:
Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased.
Conclusion:
High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
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