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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

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Related Experiment Video

Updated: Mar 2, 2026

Transplantation of Adipose Tissue-Derived Stem Cell Sheet to Reduce Leakage After Partial Colectomy in A Rat Model

Transplantation of Adipose Tissue-Derived Stem Cell Sheet to Reduce Leakage After Partial Colectomy in A Rat Model

Published on: August 11, 2018

Improvement of Anal Function by Adipose-Derived Stem Cell Sheets.

Yusuke Inoue¹, Fumihiko Fujita, Izumi Yamaguchi

¹Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Digestive Surgery

|May 12, 2017

Summary

Adipose-derived stem cell (ADSC) sheets significantly improved anal sphincter function in a rat model after surgery. This regenerative therapy shows promise for treating anal sphincter dysfunction caused by anorectal procedures.

Keywords:

Adipose-derived stem cell Anal dysfunction model Cell sheet Intersphincteric resection Rat

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ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

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Last Updated: Mar 2, 2026

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Published on: August 11, 2018

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Published on: February 10, 2017

Area of Science:

Regenerative medicine
Biotechnology
Gastroenterology

Background:

Anal sphincter dysfunction is a common complication following anorectal surgery.
Current treatments for anal sphincter dysfunction have limitations.

Purpose of the Study:

To evaluate the efficacy of adipose-derived stem cell (ADSC) sheets in restoring anal sphincter function.
To assess the potential of ADSC sheets as a novel biotechnological approach for treating anal sphincter dysfunction.

Main Methods:

An animal model using Sprague-Dawley rats with resected anal sphincters was developed.
ADSC sheets were transplanted into the resected area in the experimental group; a control group received no transplantation.
Anal function was assessed by measuring resting pressure, and smooth muscle regeneration was evaluated histologically.

Main Results:

Rats treated with ADSC sheets demonstrated significantly improved anal pressure compared to the control group.
Histological analysis revealed smooth muscle regeneration in the vicinity of the remaining muscle tissue.
Fluorescence in situ hybridization confirmed that the regenerated cells originated from the recipient.

Conclusions:

Regenerative therapy utilizing ADSC sheets holds potential for recovering anal sphincter function.
ADSC sheet transplantation offers a promising solution for anal sphincter dysfunction resulting from anorectal surgery.