Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oncogenes and tumor suppressor genes.

G Klein1

  • 1Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.

Acta Oncologica (Stockholm, Sweden)
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feasibility of an implantable arrhythmia monitor.

Pacing and clinical electrophysiology : PACE·1992
Same author

Nuclear colocalization of c-myc protein and hsp70 in cells transfected with human wild-type and mutant c-myc genes.

Experimental cell research·1992
Same author

Decreased expression of E-cadherin and increased invasive capacity in EBV-LMP-transfected human epithelial and murine adenocarcinoma cells.

International journal of cancer·1992
Same author

Laminin in the male germ cells of Drosophila.

The Journal of cell biology·1992
Same author

Ubiquinone (coenzyme Q10) in the long-term treatment of idiopathic dilated cardiomyopathy.

European heart journal·1992
Same author

Alfentanil-midazolam anaesthesia has no electrophysiological effects upon the normal conduction system or accessory pathways in patients with Wolff-Parkinson-White syndrome.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·1992

Retroviruses carrying oncogenes can cause cancer by altering cell division genes. These oncogenes, including growth factors and receptors, drive tumor development through various genetic changes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Virology

Background:

  • Artificial selection of RNA tumor viruses yields defective retroviral genomes.
  • These genomes acquire host genes influencing cell division via recombination.

Purpose of the Study:

  • To identify and categorize genes that, when altered by retroviruses, contribute to cancer.
  • To understand the mechanisms by which these genes promote tumor development and progression.

Main Methods:

  • Analysis of retroviral genomes isolated after artificial selection for high transforming ability.
  • Identification of acquired host genes involved in cell division regulation.

Main Results:

  • Four functional groups of cell division genes are implicated in oncogenesis.

Related Experiment Videos

  • Mechanisms include autocrine growth factor signaling (sis), truncated growth factor receptors (erb-B, fms), mutated signal transduction proteins (ras-family), and activated DNA-binding proteins (myc-family).

    • Conclusions:

    • Acquisition and activation of host cell division genes by retroviruses are key mechanisms in viral oncogenesis.
    • Specific gene families (growth factors, receptors, signal transducers, DNA-binding proteins) play critical roles in tumor initiation and progression.