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m6A Modification and Implications for microRNAs

Ayse Elif Erson-Bensan1, Oguzhan Begik1

  • 1Department of Biological Sciences, Middle East Technical University (METU), Ankara, 06800. Turkey.

Microrna (Shariqah, United Arab Emirates)
|May 13, 2017
PubMed
Abstract

Insights

Methylation of Adenine (m6A) is a key RNA modification impacting gene regulation. This review explores m6A

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Gene Regulation

Background:

  • Over 100 chemical modifications exist for RNA.
  • RNA methylation, specifically N6-methyladenosine (m6A), is a prevalent and extensively studied modification.
  • m6A is implicated in various biological processes.

Purpose of the Study:

  • To review recent literature on m6A modification.
  • To explore the implications of m6A in microRNA (miRNA)-mediated gene expression regulation.
  • To elucidate the roles of m6A in miRNA biogenesis, mRNA-miRNA interactions, and m6A target selection.

Main Methods:

  • Literature review of recent studies on m6A modification.
  • Analysis of m6A's role in miRNA biogenesis.
  • Investigation of m6A's influence on mRNA-miRNA interactions and target selection.

Main Results:

  • m6A modification is widespread across the transcriptome.
  • m6A plays a significant role in regulating gene expression through miRNA pathways.
  • Specific implications include effects on miRNA biogenesis, mRNA-miRNA binding, and m6A target recognition.

Conclusions:

  • Understanding m6A is crucial for deciphering complex transcriptome regulation.
  • m6A's role in gene regulation is significant in both normal physiological and disease states.
  • Further research into m6A functions will enhance our knowledge of cellular processes.
Keywords:
3'UTRRNA methylationm6AmRNAmicroRNAtranscriptome

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