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Multiplexed Spike Coding and Adaptation in the Thalamus.

Rebecca A Mease1, Thomas Kuner2, Adrienne L Fairhall3

  • 1Department of Neurosurgery, Technische Universität München, Munich 81675, Germany; Neurobiology and Behavior Graduate Program, University of Washington, Seattle, WA 98195, USA.

Cell Reports
|May 13, 2017
PubMed
Summary
This summary is machine-generated.

Neurons use spike bursts to encode information. Thalamic neurons multiplex low- and high-frequency stimuli using calcium and sodium spikes, encoding data in burst size, onset time, and precise spike timing within bursts.

Keywords:
T-type calcium channeladaptationburstingexcitabilitylinear-nonlinear modelmultiplexingneural codingthalamocortical system

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Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Neuronal "burst" clusters of spikes are a common output pattern across species.
  • The mechanism by which synaptic inputs are encoded by neuronal bursts is not fully understood.

Purpose of the Study:

  • To investigate how bursting neurons in the rodent thalamus encode synaptic inputs.
  • To elucidate the role of different spiking events (calcium and sodium) in burst encoding.

Main Methods:

  • Analysis of high-frequency spike burst patterns in rodent thalamic neurons.
  • Investigating the differential encoding of low- and high-frequency stimuli.
  • Examining adaptation properties of T-type calcium and fast sodium spiking events.

Main Results:

  • Thalamic bursting neurons "multiplex" information, differentially encoding low- and high-frequency stimuli.
  • Encoding occurs through three channels: burst size, burst onset time, and precise intraburst spike timing.
  • The intraburst spike timing channel exhibits millisecond-level selectivity and adapts to maintain stable information encoding.

Conclusions:

  • Neuronal bursts efficiently convey fine-scale temporal information.
  • Calcium events encode low-frequency stimuli and gate a window for high-frequency encoding via sodium spike timing.
  • This multiplexing strategy allows thalamic neurons to process complex temporal information.