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Updated: Mar 2, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Early predictors of rapidly evolving multiple sclerosis: A case report.

Kryshani T M Fernando1, Michael James2

  • 1Department of Neurology, Watford General Hospital, Hertfordshire, United Kingdom; Department of Neurology, Royal Free Hospital, London, United Kingdom.

Journal of Neuroimmunology
|May 13, 2017
PubMed
Summary

Rapidly evolving Multiple Sclerosis (MS) can be predicted by early relapse, high CSF white cell counts, and specific MRI findings. Early identification and treatment, including plasma exchange, are crucial for managing severe MS cases.

Area of Science:

  • Neurology
  • Immunology
  • Radiology

Background:

  • Multiple Sclerosis (MS) can rarely present as a fulminant disease with severe relapses, leading to significant morbidity and mortality.

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  • Early identification of rapidly evolving MS is crucial for effective management, but data on its natural history and treatment is limited due to its rarity.