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Updated: Mar 2, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives
Dan He1, Menglei Wang1, Siyu Zhao1
1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
Abstract:
Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted increasing interest because of their broad spectrum of biological functions. This review describes three types of natural quinazolinones and their synthesized derivatives and summarizes their various pharmacological activities, including antifungal, anti-tumor, anti-malaria, anticonvulsant, anti-microbial, anti-inflammatory and antihyperlipidemic activities. In addition, structure-activity relationships of quinazolinone derivatives are also reviewed.
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