Prediction of local control in early glottic carcinoma using the maximum standardised uptake value

This retrospective study aimed to determine whether the maximum standardised uptake value (SUV_max) can predict local tumour control in early glottic cancer (Tis, T1, and T2).

Fifty-nine patients treated with definitive radiotherapy for early glottic cancer between 2003 and 2011 were enrolled. We evaluated the SUV_max in the region of interest around the original tumour site. Local tumour control and survival were estimated using Kaplan-Meier curves. Receiver operating characteristic curves were used to assess the optimal SUV_max cut-off for predicting local control.

As determined by laryngoscopy, all patients achieved a complete response. Eleven patients experienced local recurrence, while no distant metastasis occurred. One patient died due to local recurrence, while five lost their larynxes. The median follow-up was 61.5 (range: 6.2-123.4) months. The five-year local progression-free survival was 84.7%, and larynx preservation was possible in 89.6% of cases. The median SUV_max was 2.2. The optimal SUV_max for predicting local tumour control was identified as 3.4. Patients with glottic cancers with an SUV_max>3.4 showed a significantly lower local progression-free survival rate than those with tumours with an SUV_max<3.4 (five-year local progression-free survival rate: 53.4% vs. 95.4%, P<0.01). Multivariate analysis confirmed that a high SUV_max was an independent predictive factor for local progression-free survival (P=0.006).

The use of (¹⁸F)-fluorodeoxyglucose-positron emission tomography for evaluation of the SUV_max is useful to predict local progression-free survival in patients with early glottic cancer treated by radiation. Early glottic cancer with a high SUV_max may require aggressive local treatment and careful surveillance.