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Insights on Heme Synthesis in the Malaria Parasite
Viswanathan A Nagaraj1, Govindarajan Padmanaban2
1Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar 751023, Odisha, India.
Trends in Parasitology
|May 13, 2017
Abstract:
The malaria parasite has a functional heme-biosynthetic pathway, although it can access host hemoglobin-heme. The heme pathway is dispensable for blood stages, but essential in the mosquito stages which do not acquire hemoglobin-heme. We propose that the blood stage parasites maintain a dynamic heme pool through multiple back-up mechanisms.

