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Improving core outcome set development: qualitative interviews with developers provided pointers to inform guidance.

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Summary
This summary is machine-generated.

Core outcome set (COS) development presents challenges, particularly regarding patient involvement and funding. Guidance is needed to strengthen COS development processes, emphasizing context-specific approaches.

Keywords:
ConsensusCore outcome setsDelphiInterviewOutcomesQualitative researchResearch methodology

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Area of Science:

  • Health Services Research
  • Methodology

Background:

  • Core Outcome Sets (COS) are increasingly important in clinical research.
  • Developing COS involves complex methodological and practical challenges.

Purpose of the Study:

  • To explore the experiences of Core Outcome Set (COS) developers.
  • To inform methodological guidance for COS development.
  • To identify areas for future research in COS methodology.

Main Methods:

  • Semistructured interviews were conducted with 32 purposively selected COS developers.
  • Interview transcripts were analyzed using constant comparative and framework analysis.

Main Results:

  • COS development is perceived as challenging, especially concerning patient participation and funding acquisition.
  • Developers questioned the status of COS development (consultation vs. research) and highlighted the impact of lacking guidance.
  • Key areas identified for guidance included patient participation, ethics, international collaboration, and implementation, with specific interest in systematic reviews, Delphi, and consensus meetings.

Conclusions:

  • The study underscores critical questions regarding the funding, status, and processes of COS development.
  • Methodological guidance can strengthen COS development, but must avoid over-specification to maintain quality.
  • Guidance should focus on common considerations while promoting context-specific tailoring of COS development.