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Updated: Mar 2, 2026

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
[Slowly progressive Basaloid Squamous Cell Carcinoma of the Lung]
Kazuma Kobayashi1, Koutaro Abe, Naoya Ishibashi
1Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Abstract:
Basaloid squamous cell carcinoma (BSC) of the lung is a rare variant of squamous cell carcinoma (SCC) and is reported to show poor prognosis. A 70-year-old man presented to the clinic complaining of a productive cough. Computed tomography( CT) of the chest revealed a nodule in the left lower lobe of the lung. A bronchoscopy and transbronchial lung biopsy(TBB) were performed twice;no evidence of malignancy was found. So we followed up by periodic chest CT. One year and 4 months after the 1st visit, the nodule increased in size from 14 to 19 mm. TBB was performed again and the tumor was diagnosed as SCC. The patient underwent a left lower lobectomy and the tumor was diagnosed as BSC by postoperative pathological examination. Two years and 6 months after surgery, no recurrence has been observed in the patient.
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