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Updated: Mar 2, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives
Daniel T Payne1, Yiming Zhao2, John S Fossey3
1School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK. dxp854@bham.ac.uk.
Abstract:
Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11-67% yield from aldehydes. Aldehydes were reacted with Meldrum's acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrolysis decarboxylation generated the corresponding 3-propanoic acid derivatives. The -propanoic acid derivatives were reduced to give 3-propanol derivatives, which were readily oxidised to target 3-propanal derivatives.
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