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Biochemical and High Throughput Microscopic Assessment of Fat Mass in Caenorhabditis Elegans

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Epigenetics of Lipid Phenotypes.

Sergi Sayols-Baixeras¹, Marguerite R Irvin², Donna K Arnett³

¹Cardiovascular Epidemiology and Genetics Group, Institut Hospital del Mar d'Investigacions Mediques (IMIM), Dr. Aiguader, 88, Barcelona 08003, Spain, Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain, (tel) 34-93-316-07-27, (fax) 34-93-316-04-10.

Current Cardiovascular Risk Reports

|May 13, 2017

Summary

Epigenetics, including DNA methylation and RNA regulation, influences blood lipid levels and cardiovascular disease risk. Further research is needed to translate these findings into effective dyslipidemia therapies.

Keywords:

Cholesterol Epigenetics Lipids Methylation Triglycerides

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Area of Science:

Biochemistry
Genetics
Molecular Biology

Background:

Dyslipidemia is a major risk factor for cardiovascular disease globally.
Blood lipid profiles are influenced by both genetic and environmental factors.
Epigenetics offers a unifying framework for understanding these influences.

Purpose of the Study:

To review the latest evidence on epigenetic mechanisms in lipid homeostasis.
To highlight key epigenetic findings in genes and microRNAs related to lipid metabolism.
To discuss the potential and limitations of epigenetic insights for dyslipidemia therapy.

Main Methods:

Literature review of recent evidence on epigenetics and lipid homeostasis.
Focus on DNA methylation, histone modification, and RNA regulation.
Analysis of findings from animal and cell culture models.

Main Results:

Epigenetic mechanisms, including DNA methylation, histone modification, and RNA regulation, play a role in lipid homeostasis.
Novel epigenetic loci in genes like CPT1A, ABCG1, and SREBF1, and microRNA-33a/b have been identified.
Complex interplay between epigenetic processes in lipid-related genomic regions is suggested by model systems.

Conclusions:

Epigenetic findings can explain interindividual variability in lipid profiles.
Current epigenetic research holds potential for understanding dyslipidemia mechanisms.
Translation of epigenetic discoveries into effective dyslipidemia therapies is still pending.