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Impact of Metabolic Syndrome on Ablation-Outcome in Patients with Atrial Fibrillation: A Systematic Review

Sanghamitra Mohanty1,2, Luigi Di Biase1,3,4, Prasant Mohanty1

  • 1St. David?s Medical Center, Texas Cardiac Arrhythmia Institute, Austin, Texas.

Journal of Atrial Fibrillation
|May 13, 2017
PubMed

Insights

Metabolic syndrome (MS) is linked to atrial fibrillation (AF), but its role in AF persistence and ablation success needs more study. Lifestyle changes may improve AF ablation outcomes by managing MS components.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Electrophysiology

Background:

  • Metabolic syndrome (MS) is a pro-inflammatory condition characterized by hypertension, diabetes, dyslipidemia, and obesity.
  • MS is strongly associated with atrial fibrillation (AF), a common cardiac arrhythmia.
  • The precise mechanisms linking MS to AF perpetuation and its impact on AF ablation outcomes remain incompletely understood.

Purpose of the Study:

  • To review current literature on the relationship between MS and AF.
  • To elucidate the role of MS components and the syndrome as a whole in AF.
  • To assess the influence of MS on the success rates of AF ablation procedures.

Main Methods:

  • Systematic review of major studies investigating MS, its components, and AF.
  • Analysis of data concerning the impact of MS on AF perpetuation.
  • Evaluation of evidence regarding the effect of MS on AF ablation outcomes.

Main Results:

  • MS significantly influences the perpetuation of AF through various pro-inflammatory pathways.
  • Individual components of MS, as well as the overall syndrome, affect the success of AF ablation.
  • Evidence suggests that addressing MS components through lifestyle modifications can potentially improve AF ablation success rates.

Conclusions:

  • Metabolic syndrome is a critical factor in AF pathogenesis and influences ablation outcomes.
  • Further research is needed to fully understand the mechanistic links between MS and AF.
  • Lifestyle interventions targeting MS components represent a promising strategy to enhance AF ablation efficacy.

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