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Role of Stress in Cardiac Arrhythmias
Vladimir Shusterman1, Rachel Lampert1
1University of Pittsburgh School of Medicine and Yale University School of Medicine.
Insights
Stress significantly impacts heart rhythm, triggering arrhythmias through the autonomic nervous system (ANS). This review examines how psychological and circadian stressors affect ANS activity and contribute to atrial arrhythmias.
Area of Science:
- Cardiology
- Neuroscience
- Physiology
Background:
- Stress is a primary factor in triggering cardiac arrhythmias.
- Stressors affect cardiac electrophysiology and rhythm via the autonomic nervous system (ANS).
- Autonomic cardiovascular responses to stressors share common properties, allowing independent study.
Purpose of the Study:
- To review clinical and experimental evidence linking common stressors to atrial arrhythmias.
- To describe the impact of psychological and circadian stressors on ANS activity and arrhythmogenesis.
- To examine the relationship between autonomic cardiovascular responses and cardiac arrhythmias.
Main Methods:
- Review of clinical evidence.
- Review of experimental studies.
- Analysis of studies in ambulatory and laboratory settings.
Main Results:
- Stressors significantly influence cardiac electrophysiology and rhythm.
- Psychological and circadian stressors modulate ANS activity, promoting arrhythmogenesis.
- Evidence links autonomic cardiovascular responses to atrial arrhythmias in various settings.
Conclusions:
- Stress is a critical determinant of cardiac arrhythmia development.
- Understanding the ANS response to stressors is key to managing atrial arrhythmias.
- Further research on autonomic cardiovascular responses can elucidate arrhythmia mechanisms.
Abstract:
Stress is a major trigger of cardiac arrhythmias; it exerts profound effects on electrophysiology of the cardiomyocytes and the cardiac rhythm. Psychological and physiological stressors impact the cardiovascular system through the autonomic nervous system (ANS). While stressors vary, properties of the stress response at the level of cardiovascular system (collectively referred to as the autonomic cardiovascular responses) are similar and can be studied independently from the properties of specific stressors. Here, we will review the clinical and experimental evidence linking common stressors and atrial arrhythmias. Specifically, we will describe the impact of psychological and circadian stressors on ANS activity and arrhythmogenesis. We will also review studies examining relationships between autonomic cardiovascular responses and cardiac arrhythmias in ambulatory and laboratory settings.
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