CHADS2 and CHA2DS2Vasc-Score in Peripheral Systemic Embolism

Frans Santosa1, Thomas Nowak1, Theodoros Moysidis1

  • 1Department of Vascular Medicine.

Insights

Patients with acute peripheral embolism often have atrial fibrillation (AF). Most patients with AF and peripheral embolism meet criteria for oral anticoagulation therapy based on CHADS2 and CHA2DS2-Vasc scores.

Area of Science:

  • Vascular Medicine
  • Cardiology
  • Thrombosis

Background:

  • Acute peripheral embolism is a significant clinical event.
  • Risk stratification scores like CHADS2 and CHA2DS2-Vasc are used to assess stroke risk in atrial fibrillation patients.

Purpose of the Study:

  • To analyze patient characteristics with acute peripheral embolic events.
  • To evaluate the applicability of CHADS2 and CHA2DS2-Vasc scores in this patient group.

Main Methods:

  • Retrospective analysis of 163 patients with acute peripheral arterial embolism (2008-2011).
  • Screening of medical records for atrial fibrillation (AF) and risk factors for CHADS2 and CHA2DS2-Vasc scores.

Main Results:

  • Hypertension and age >75 were common risk factors.
  • Mean CHA2DS2-Vasc scores were 3.6 in males and 4.6 in females.
  • 48% of patients had documented AF; most scored high on risk stratification scales.
  • Inadequate anticoagulation (INR <2) was noted in 90% of AF patients on phenprocoumon.

Conclusions:

  • A high prevalence of AF exists in patients with acute peripheral embolism.
  • Most patients with AF and peripheral embolism qualify for oral anticoagulation based on risk scores.
  • Current anticoagulation practices in these patients may be suboptimal.

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
537
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
1.3K
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
563
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
1.0K
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
399
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
342