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CHADS2 and CHA2DS2Vasc-Score in Peripheral Systemic Embolism
Frans Santosa1, Thomas Nowak1, Theodoros Moysidis1
1Department of Vascular Medicine.
Insights
Patients with acute peripheral embolism often have atrial fibrillation (AF). Most patients with AF and peripheral embolism meet criteria for oral anticoagulation therapy based on CHADS2 and CHA2DS2-Vasc scores.
Area of Science:
- Vascular Medicine
- Cardiology
- Thrombosis
Background:
- Acute peripheral embolism is a significant clinical event.
- Risk stratification scores like CHADS2 and CHA2DS2-Vasc are used to assess stroke risk in atrial fibrillation patients.
Purpose of the Study:
- To analyze patient characteristics with acute peripheral embolic events.
- To evaluate the applicability of CHADS2 and CHA2DS2-Vasc scores in this patient group.
Main Methods:
- Retrospective analysis of 163 patients with acute peripheral arterial embolism (2008-2011).
- Screening of medical records for atrial fibrillation (AF) and risk factors for CHADS2 and CHA2DS2-Vasc scores.
Main Results:
- Hypertension and age >75 were common risk factors.
- Mean CHA2DS2-Vasc scores were 3.6 in males and 4.6 in females.
- 48% of patients had documented AF; most scored high on risk stratification scales.
- Inadequate anticoagulation (INR <2) was noted in 90% of AF patients on phenprocoumon.
Conclusions:
- A high prevalence of AF exists in patients with acute peripheral embolism.
- Most patients with AF and peripheral embolism qualify for oral anticoagulation based on risk scores.
- Current anticoagulation practices in these patients may be suboptimal.
Abstract:
Objectives: We analysed the characteristics of patients with an acute peripheral embolic event considering the possible use of the CHADS2-Score and the CHA2DS2Vasc-Score Patients and Methods: We retrospectively analyzed 163 cases of acute peripheral arterial embolism treated in the Department of Vascular Medicine of the HELIOS Klinik Krefeld, Germany, from 2008 to 2011. We retrospectively screened the medical form for information regarding atrail fibrillation (AF) and the risk factors necessary to calculate the CHADS2 and CHA2DS2vasc score. Results: Arterial hypertension and age > 75 years were the most frequent risk factors. Mean CHADS2 score was similar in males and females (2.3 ± 1.5 and 2.3 ± 1.4). 66% of the males and 63.3% of the females scored 2 and more points. Mean CHA2DS2Vasc score was 3.6 ± 2.0 in males and 4.6 ± 1.9 in females. 85.2% of the males and 95.4% of the females scored more than 2 points. In the medical forms AF was documented in 79 (48%) patients, of which 23 (43 %) were males and 56 (51%) females. Mean CHADS2 score and mean CHA2DS2Vasc score were slightly higher in those with AF compared to the total group, but not significantly different. The rate of patients with 2 and more points increased for both scores: CHADS2 score: males 82.6% and females 76.8%, CHA2DS2Vasc: males 100% and females 98.2%. Almost half of the patients with AF had had anticoagulation with phenprocoumon before (males 12 (52%), females 24 (43%), but only every 10th was within the therapeutic range (INR ≥2) Conclusion: The number of those with AF is high amongst patients with acute peripheral embolism. According to the CHADS2 and CHA2DS2Vasc score, most of these patients had an indication for oral anticoagulation independent form the embolic event.
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