A Review of the Value of Procalcitonin as a Marker of Infection

Septicemia is a growing problem within the United States (US), which increases mortality and the cost of care. Procalcitonin is a pro-inflammatory marker that could be useful in the diagnosis of infection. In the past, procalcitonin levels have been evaluated to diagnose sepsis or guide antibiotic therapy, but it was not determined if it would differentiate between sepsis and other causes of inflammation. Studies reviewed here showed procalcitonin to be a useful biomarker as an indication of bacterial infection. Infections can be diagnosed earlier and managed appropriately to avoid progression to septicemia, reduce mortality, and overall medical costs.