Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimal dithiocarbamate structure for immunomodulator action.

R J Topping1, M M Jones

  • 1Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235.

Medical Hypotheses
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Semipermeable species boundaries create opportunities for gene flow and adaptive potential.

Molecular ecology·2023
Same author

[Morphological changes in rabbit cornea after implantation of a new keratoprosthesis supporting plate].

Vestnik oftalmologii·2020
Same author

The C-terminal region of the major outer sheath protein of Treponema denticola inhibits neutrophil chemotaxis.

Molecular oral microbiology·2017
Same author

Long-term findings from COMFORT-II, a phase 3 study of ruxolitinib vs best available therapy for myelofibrosis.

Leukemia·2017
Same author

Long-term findings from COMFORT-II, a phase 3 study of ruxolitinib vs best available therapy for myelofibrosis.

Leukemia·2016
Same author

Sampling Methods for Detection and Monitoring of the Asian Citrus Psyllid (Hemiptera: Psyllidae).

Environmental entomology·2015
Same journal

Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

Medical hypotheses·2026
Same journal

Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

Medical hypotheses·2025
Same journal

The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

Medical hypotheses·2025
Same journal

Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

Medical hypotheses·2025
Same journal

How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

Medical hypotheses·2024
Same journal

Unstable Plaque is a Treatable Cause of Cognitive Decline.

Medical hypotheses·2024
See all related articles

New dithiocarbamates, sodium pyrrolidinedithiocarbamate (PDTC) and sodium di-n-propyldithiocarbamate (DPDTC), show superior stability over sodium diethyldithiocarbamate (DEDTC) for potential AIDS treatment, especially via oral administration.

Area of Science:

  • Pharmacology and Medicinal Chemistry
  • Virology and Infectious Diseases

Background:

  • Sodium diethyldithiocarbamate (DEDTC) has been explored for treating Acquired Immunodeficiency Syndrome (AIDS).
  • Chemical stability at physiological pH (7.4) is a critical factor for drug efficacy in vivo.
  • Existing dithiocarbamates may have limitations in stability, impacting their therapeutic potential.

Purpose of the Study:

  • To identify and evaluate alternative dithiocarbamate compounds with enhanced chemical stability at pH 7.4.
  • To assess the potential of more stable dithiocarbamates for improved efficacy in AIDS treatment.
  • To compare the stability and lipophilicity of novel dithiocarbamates with the established DEDTC.

Main Methods:

  • Chemical analysis of dithiocarbamate stability at physiological pH.

Related Experiment Videos

  • Evaluation of hydrolysis rates and half-lives at pH 7.4.
  • Assessment of lipophilicity to predict pharmacokinetic properties.

    • Main Results:

    • Sodium pyrrolidinedithiocarbamate (PDTC) and sodium di-n-propyldithiocarbamate (DPDTC) exhibit significantly longer half-lives at pH 7.4 compared to DEDTC.
    • PDTC and DPDTC are expected to possess similar lipophilicity to DEDTC.
    • The enhanced stability suggests superior performance, particularly for oral drug delivery.

    Conclusions:

    • PDTC and DPDTC represent promising candidates for AIDS therapy due to their superior hydrolytic stability.
    • These compounds may offer advantages over DEDTC, especially for oral administration routes.
    • Further investigation into the therapeutic efficacy of PDTC and DPDTC in AIDS treatment is warranted.