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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

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An update on diabetic kidney disease, oxidative stress and antioxidant agents

Leila Mahmoodnia1, Esmat Aghadavod2, Sara Beigrezaei3

  • 1Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Journal of Renal Injury Prevention
|May 13, 2017
PubMed

Insights

Diabetic kidney disease stems from diabetes mellitus, a condition of insulin deficiency. Oxidative stress, driven by free radicals and reduced antioxidants, significantly contributes to kidney damage in diabetic patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • Diabetes mellitus is a metabolic disorder characterized by insulin deficiency.
  • Diabetic kidney disease is a common complication of diabetes.
  • Oxidative stress plays a crucial role in the development of diabetic kidney disease.

Purpose of the Study:

  • To elucidate the role of oxidative stress in diabetic kidney disease pathogenesis.
  • To explore the signaling pathways involved in diabetes-induced oxidative stress and kidney damage.

Main Methods:

  • Review of existing evidence on oxidative stress markers in diabetes.
  • Analysis of signaling pathways activated by reactive oxygen species (ROS) in kidney tissue.
  • Correlation of oxidative stress with structural and functional kidney changes.

Main Results:

  • Diabetic state elevates oxidative stress through increased free-radical formation and/or decreased antioxidant defenses.
  • Reactive oxygen species (ROS) activate downstream signaling cascades.
  • These cascades lead to structural and functional alterations in the kidney.

Conclusions:

  • Oxidative stress is a key factor in the pathogenesis of diabetic kidney disease.
  • Understanding these pathways can inform therapeutic strategies for diabetic nephropathy.
Keywords:
AntioxidantDiabetes mellitusKidney diseaseOxidative stress

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