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[Delayed primary operation of solid tumors in children].
N Ohnuma1, H Takahashi, M Maie
1Department of Pediatric Surgery, School of Medicine, Chiba University, Japan.
Nihon Geka Gakkai Zasshi
|November 1, 1988
Summary
Delayed primary operations with preoperative chemotherapy improve outcomes for childhood solid tumors like neuroblastoma. Optimal timing involves 2-3 chemotherapy courses before surgery for easier tumor removal.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Chemotherapy
Context:
- Delayed primary operations for childhood solid tumors initiated in 1982.
- Treatment of 19 pediatric solid tumor cases including advanced neuroblastoma, hepatoblastoma, and sacrococcygeal yolk sac tumors.
Purpose:
- To evaluate the effectiveness of preoperative chemotherapy in delayed primary operations.
- To determine optimal surgical timing post-chemotherapy.
- To discuss surgical techniques for these complex cases.
Summary:
- Preoperative chemotherapy demonstrated significant utility in most cases, facilitating easier removal of primary tumors and lymph node metastases.
- The recommended optimal timing for surgery is after 2-3 courses of preoperative chemotherapy.
- Cavitron Ultrasonic Surgical Aspirator (CUSA) proved effective for complete tumor and metastasis removal in advanced neuroblastoma, preserving renal function.
Impact:
- Highlights the benefits of neoadjuvant chemotherapy in pediatric solid tumors.
- Provides guidance on surgical timing and techniques for improved patient outcomes.
- Demonstrates the value of advanced surgical tools like CUSA in complex pediatric cancer surgery.