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Updated: Mar 2, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation
Utako Oba1, Hiroshi Yamada1, So-Ichi Suenobu1
1Department of Pediatrics, Oita University Faculty of Medicine, Oita University, Oita, Japan.
Abstract:
TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Although we did not evaluate the T-cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN.
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